High asymptomatic carriage with the Omicron variant in South Africa

N Garrett, A Tapley, J Andriesen… - Clinical Infectious …, 2022 - academic.oup.com
N Garrett, A Tapley, J Andriesen, I Seocharan, LH Fisher, L Bunts, N Espy, CL Wallis…
Clinical Infectious Diseases, 2022academic.oup.com
We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS
CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South
Africa, 15-fold higher than in trials before Omicron. We also found lower CD4+ T-cell counts
in persons with human immunodeficiency virus (HIV) strongly correlated with increased
odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.
Abstract
We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4 + T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.
Oxford University Press