[PDF][PDF] Cardiac effects of 3, 5-diiodothyropropionic acid, a thyroid hormone analog with inotropic selectivity
GD Pennock, TE Raya, JJ Bahl, S Goldman… - … of Pharmacology and …, 1992 - prizmtx.com
GD Pennock, TE Raya, JJ Bahl, S Goldman, E Morkin
Journal of Pharmacology and Experimental Therapeutics, 1992•prizmtx.comThyroid hormone exerts a strong positive inotropic action on the heart and induces a-myosin
heavy chain (MHC) gene expression. 3, 5-Diiodothyropropionic acid (DITPA), a carboxylic
acid analog with low metabolic activity, was observed to induce a-MHC mRNA in heart cell
cufture with ECso 5 X 10 M. To determine if the compound has positive inotropic actions, the
effects of
heavy chain (MHC) gene expression. 3, 5-Diiodothyropropionic acid (DITPA), a carboxylic
acid analog with low metabolic activity, was observed to induce a-MHC mRNA in heart cell
cufture with ECso 5 X 10 M. To determine if the compound has positive inotropic actions, the
effects of
Abstract
Thyroid hormone exerts a strong positive inotropic action on the heart and induces a-myosin heavy chain (MHC) gene expression. 3, 5-Diiodothyropropionic acid (DITPA), a carboxylic acid analog with low metabolic activity, was observed to induce a-MHC mRNA in heart cell cufture with ECso 5 X 10 M. To determine if the compound has positive inotropic actions, the effects of
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