Subclinical hypothyroidism, mood, and cognition in older adults: a review
RT Joffe, EN Pearce, JV Hennessey… - … journal of geriatric …, 2013 - Wiley Online Library
RT Joffe, EN Pearce, JV Hennessey, JJ Ryan, RA Stern
International journal of geriatric psychiatry, 2013•Wiley Online LibraryObjectives To perform a critical review of the literature on the mood and cognitive changes
associated with subclinical hypothyroidism (SCH), with an emphasis on older adults. To
evaluate these data against the Consensus Statement on the management of SCH from the
American Association of Clinical Endocrinologists, the American Thyroid Association, and
The Endocrine Society. Method A comprehensive literature review. Results Subclinical
hypothyroidism may be associated with an increased risk of mood and cognitive dysfunction …
associated with subclinical hypothyroidism (SCH), with an emphasis on older adults. To
evaluate these data against the Consensus Statement on the management of SCH from the
American Association of Clinical Endocrinologists, the American Thyroid Association, and
The Endocrine Society. Method A comprehensive literature review. Results Subclinical
hypothyroidism may be associated with an increased risk of mood and cognitive dysfunction …
Objectives
To perform a critical review of the literature on the mood and cognitive changes associated with subclinical hypothyroidism (SCH), with an emphasis on older adults. To evaluate these data against the Consensus Statement on the management of SCH from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society.
Method
A comprehensive literature review.
Results
Subclinical hypothyroidism may be associated with an increased risk of mood and cognitive dysfunction, although the strength of this association and the efficacy of replacement hormone therapy require further investigation.
Conclusion
It remains unclear whether SCH leads to significant mood and cognitive impairments in most older patients. More research is required to determine the nature and extent of this association and whether thyroid hormone replacement therapy is appropriate and effective in treating SCH‐associated neurobehavioral impairments. Copyright © 2012 John Wiley & Sons, Ltd.
Wiley Online Library