The TGF-β superfamily is an ancient metazoan protein class which cuts across cell and
tissue differentiation, developmental biology and immunology. Its many members are
regulated at multiple levels from intricate control of gene transcription, post-translational
processing and activation, and signaling through overlapping receptor structures and
downstream intracellular messengers. We have been interested in TGF-β homologues firstly
as key players in the induction of immunological tolerance, the topic so closely associated …