[HTML][HTML] Correlation between PD-1/PD-L1 expression and polarization in tumor-associated macrophages: A key player in tumor immunotherapy
W Li, F Wu, S Zhao, P Shi, S Wang, D Cui - Cytokine & Growth Factor …, 2022 - Elsevier
Tumor immunotherapy, such as PD-1/PD-L1 blockade, has shown promising clinical efficacy
in patients with various types of tumors. However, the response to PD-1/PD-L1 blockade in a
majority of malignancies is limited, indicating an urgent need for a deeper understanding of
the mechanisms of PD-1/PD-L1 axis-mediated tumor tolerance. As the most abundant
immune cells in the tumor stroma, macrophages display multiple phenotypes and functions
in response to the stimuli of the tumor microenvironment. PD-1/PD-L1 has been …
in patients with various types of tumors. However, the response to PD-1/PD-L1 blockade in a
majority of malignancies is limited, indicating an urgent need for a deeper understanding of
the mechanisms of PD-1/PD-L1 axis-mediated tumor tolerance. As the most abundant
immune cells in the tumor stroma, macrophages display multiple phenotypes and functions
in response to the stimuli of the tumor microenvironment. PD-1/PD-L1 has been …
