[HTML][HTML] The CDK9–cyclin T1 complex mediates saturated fatty acid–induced vascular calcification by inducing expression of the transcription factor CHOP
Y Shiozaki, K Okamura, S Kohno, AL Keenan… - Journal of Biological …, 2018 - ASBMB
Vascular calcification (or mineralization) is a common complication of chronic kidney
disease (CKD) and is closely associated with increased mortality and morbidity rates. We
recently reported that activation of the activating transcription factor 4 (ATF4) pathway
through the saturated fatty acid (SFA)-induced endoplasmic reticulum (ER) stress response
plays a causative role in CKD-associated vascular calcification. Here, using mouse models
of CKD, we 1) studied the contribution of the proapoptotic transcription factor CCAAT …
disease (CKD) and is closely associated with increased mortality and morbidity rates. We
recently reported that activation of the activating transcription factor 4 (ATF4) pathway
through the saturated fatty acid (SFA)-induced endoplasmic reticulum (ER) stress response
plays a causative role in CKD-associated vascular calcification. Here, using mouse models
of CKD, we 1) studied the contribution of the proapoptotic transcription factor CCAAT …
