[HTML][HTML] Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: recent advances
H Huang - Sensors, 2018 - mdpi.com
Sensors, 2018•mdpi.com
As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a
significant protease which plays vital roles in many biological processes. MMP-9 can cleave
many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave
many plasma surface proteins to release them from the cell surface. MMP-9 has been widely
found to relate to the pathology of cancers, including but not limited to invasion, metastasis
and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to …
significant protease which plays vital roles in many biological processes. MMP-9 can cleave
many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave
many plasma surface proteins to release them from the cell surface. MMP-9 has been widely
found to relate to the pathology of cancers, including but not limited to invasion, metastasis
and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to …
As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to various specific cancers. Besides, recent research of MMP-9 biosensors discovered various novel MMP-9 biosensors to detect this enzyme. In this review, some recent advances in exploring MMP-9 as a biomarker in different cancers are summarized, and recent discoveries of novel MMP-9 biosensors are also presented.
MDPI